Weaning of nasal Continuous Positive Airway Pressure in infants born with a gestational age under 32 weeks
– a randomized controlled multicenter trial
The aim of the CPAP-trial is to investigate two different strategies for the withdrawal of nasal CPAP in preterm infants born before 32 weeks of gestation.
In a randomized controlled trial the strategy with weaning CPAP pressure to a predefined level and then stop the CPAP therapy completely will be compared to a strategy called sudden wean where the infant is taken off the CPAP therapy and stays without CPAP unless certain specific failure criteria are met.
Both strategies will primarily be compared considering the infant’s weight at a gestational age of 40 completed weeks; secondary outcomes will be the weight gain during CPAP therapy, the duration of oxygen therapy and length of stay in the NICU.